Beej Shudhi@360

The weight of the evidence suggests that increased male age is associated with a decline in semen volume, sperm motility, and sperm morphology Advancing male age has been associated with a decline in semen quality, with the largest effect being on sperm motility. Advanced paternal age appears to be associated with an increased risk of spontaneous abortion and increased frequency of some autosomal dominant conditions, autism spectrum disorders, and schizophrenia.

References

• Vascular patterns of the human testis with special reference to its senile changes.
  Sasano N, lchijo S:
  Tohoku J Exp Med 99:269, 1969
• Ageing and reproduction in the male. Bishop MW.
  Journal of Reproduction& Fertility Suppl. 1970;12:65–87.
• Ageing changes in the human testis: a light-microscopic study.
  Honoré LH.
  Gerontology.1978;24:58–65.
• Reproductive functions in young fathers and grandfathers.
  Nieschlag E, Lammers U, Freischem CW, Langer K, Wickings EJ.
  Journal of Clinical Endocrinology & Metabolism. 1982 Oct;55(4):676–681
• Influence of age on sperm production and testicular weights in men.
  Johnson L, Petty CS, Neaves WB: Journal of Reproductive Fertility 70: 211,1984
• Factors related to infertility in the United States 1965-1976.
  Mosher WD: Journal of Sexually Transmited Diseases July-September 117, 1985
• Sperm morphology in fertile men and its age related variation.
  Bujan L, Mieusset R, Mondinat C, et al.
  Andrologia. 1988;20:121–128
• Effect of Age on Male Fertility
  Sherman J. Silber, M.D.
  Seminars in Reproductive Endocrinology
  Volume 9, Number 3, August 1991
• Evidence for decreasing quality of semen during past 50 years
  Carlsen E1, Giwercman A, Keiding N, Skakkebaek NE.
BMJ(clinical research ed). 1992 Sep 12;305(6854):609-13.

• Decline in semen quality from 1930 to 1991[Article in Danish]
  Carlsen E1, Giwercman AJ, Keiding N, Skakkebaek NE.
  Ugeskr Laeger. 1993 Aug 16;155(33):2530-5.
• Decline in semen quality among fertile men in Paris during the past 20 years.
  Auger J, Kunstmann JM, Czyglik F, Jouannet P.
  New England Journal of Medicine. 1995;332:281–285
• The risk associated with pregnancy in women age 35 years or older
  M .Jolly and etal
  Human Reproduction vol.15 no 11,2000 pp 2433-2437
• Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood)
  Ford WC, North K, Taylor H, et al.
  Human Reproduction. 2000;15:1703–1708.
• Effects of male age on semen quality and fertility: a review of the literature.
  Kidd SA, Eskenazi B, Wyrobek AJ.
  Fertil Steril. 2001;75:237–248
• Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study.
  Feldman HA, Longcope C, Derby CA, et al.
  Journal of Clinical Endocrinology & Metabolism. 2002;87:589–598
• Effect of male age on fertility: evidence for the decline in male fertility with increasing age.
  Hassan MA, Killick SR.
  Fertility& Sterility. 2003;79(suppl 3):1520–1527.
• Quantitative effects of male age on sperm motion.
  Sloter E, Schmid TE, Marchetti F, et al.
  Human Reproduction. 2006;21:2868–2875.
• Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles
  Tsung-Hsien Lee, and
  Reproductive Biology and Endocrinology 2009; 7: 100.
• The Neuroendocrine physiology of female reproductive aging: an update
  Genevieve Neal-Perry, MD, PHD
  Maturitas. 2010 September ; 67(1): 34–38
• Advanced reproductive age and fertility.
  Reproductive Endocrinology and Infertility Committee; Family Physicians Advisory Committee; Maternal-Fetal Medicine Committee; Executive and Council of the Society of
  Obstetricians, Liu K, Case A.
  Journal of Obstetrics & Gynaecology Canada. 2011 Nov;33(11):1165-75.
• Delayed Child-Bearing
  Jo-Ann Johnson, MD, Calgary AB and etal
  Journal of Obstetrics & Gynaecology Canada 2012;34(1):80–93
• Sperm crisis: what crisis?
  Nieschlag E1, Lerchl A.
  Asian Journal of Andrology. 2013 Mar;15(2):184-6.
• Female age releted fertility decline
  The American college of obst gynac committee on gynac practice
  Fertility & Sterility vol 101 no 3 march 2014
• Clustering of retrospectively reported and prospectively observed time-to-pregnancy .
  Sapra KJ and etal .
  Annals of Epidemiology. 2015 Dec;25(12):959-63.